profile picture of Dylan McCreedy
  • Assistant Professor
Research Areas
  • Neurobiology

Biography

Joined the Department in 2019

Associations:

  • National Neurotrauma Society (NNS)
  • Society for Neuroscience (SFN)
  • International Society for Stem Cell Research (ISSCR)
  • Biomedical Engineering Society (BMES)
  • Society for Biomaterials (SFB)
  • Tau Beta Pi Engineering Honor Society

Research Interests

My lab investigates the roles of early inflammation in tissue damage and wound healing following spinal cord injury. We employ genetic and pharmacological methods to study how immune receptors (e.g. L-selection) and signaling pathways alter the accumulation and activation of early arriving immune cells, predominantly neutrophils. We are also developing new three-dimensional imaging strategies to characterize inflammation and tissue damage after spinal cord injury. Utilizing tissue clearing techniques and lightsheet microscopy, we can visualize the spatiotemporal effects of spinal cord injury in a manner previously unachievable with traditional imaging modalities. With the knowledge gained from these studies, we aim to develop novel neuroprotective strategies to reduce inflammatory damage and improve long-term recovery for the spinal cord injured patient.


Laboratory Details

Laboratory Address:
Interdisciplinary Life Sciences Building
Room 3128
979-458-5560

Educational Background

  • B.Sc., 2008, University of Utah, Biomedical Engineering
  • Ph.D., 2013, Washington University in St. Louis, Biomedical Engineering
  • Postdoctoral Fellow, University of Michigan/Northwestern University
  • Postdoctoral Fellow, University of California-San Francisco

Selected Publications

    1. Jensen, VN, Huffman, EE, Jalufka, FL, Pritchard, AL, Baumgartner, S, Walling, I et al.. V2a neurons restore diaphragm function in mice following spinal cord injury. Proc Natl Acad Sci U S A. 2024;121 (11):e2313594121. doi: 10.1073/pnas.2313594121. PubMed PMID:38442182 PubMed Central PMC10945804.
    2. Aceves, M, Tucker, A, Chen, J, Vo, K, Moses, J, Amar Kumar, P et al.. Publisher Correction: Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice. Commun Biol. 2023;6 (1):635. doi: 10.1038/s42003-023-05018-3. PubMed PMID:37311793 PubMed Central PMC10264442.
    3. Aceves, M, Tucker, A, Chen, J, Vo, K, Moses, J, Amar Kumar, P et al.. Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice. Commun Biol. 2023;6 (1):544. doi: 10.1038/s42003-023-04893-0. PubMed PMID:37208439 PubMed Central PMC10199026.
    4. Ni, N, Jalufka, FL, Fang, X, McCreedy, DA, Li, Q. Role of EZH2 in Uterine Gland Development. Int J Mol Sci. 2022;23 (24):. doi: 10.3390/ijms232415665. PubMed PMID:36555314 PubMed Central PMC9779349.
    5. Jalufka, FL, Min, SW, Platt, ME, Pritchard, AL, Margo, TE, Vernino, AO et al.. Hydrophobic and Hydrogel-Based Methods for Passive Tissue Clearing. Methods Mol Biol. 2022;2440 :197-209. doi: 10.1007/978-1-0716-2051-9_12. PubMed PMID:35218541 .
    6. Van Sandt, RL, Welsh, CJ, Jeffery, ND, Young, CR, McCreedy, DA, Wright, GA et al.. Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation. Am J Vet Res. 2022;83 (4):324-330. doi: 10.2460/ajvr.21.05.0073. PubMed PMID:35066481 .
    7. McCreedy, DA, Abram, CL, Hu, Y, Min, SW, Platt, ME, Kirchhoff, MA et al.. Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury. J Neuroinflammation. 2021;18 (1):302. doi: 10.1186/s12974-021-02353-2. PubMed PMID:34952603 PubMed Central PMC8705173.
    8. Gibbs, HC, Mota, SM, Hart, NA, Min, SW, Vernino, AO, Pritchard, AL et al.. Navigating the Light-Sheet Image Analysis Software Landscape: Concepts for Driving Cohesion From Data Acquisition to Analysis. Front Cell Dev Biol. 2021;9 :739079. doi: 10.3389/fcell.2021.739079. PubMed PMID:34858975 PubMed Central PMC8631767.
    9. McCreedy, DA, Jalufka, FL, Platt, ME, Min, SW, Kirchhoff, MA, Pritchard, AL et al.. Passive Clearing and 3D Lightsheet Imaging of the Intact and Injured Spinal Cord in Mice. Front Cell Neurosci. 2021;15 :684792. doi: 10.3389/fncel.2021.684792. PubMed PMID:34408627 PubMed Central PMC8366232.
    10. Massopust, RT, Lee, YI, Pritchard, AL, Nguyen, VM, McCreedy, DA, Thompson, WJ et al.. Lifetime analysis of mdx skeletal muscle reveals a progressive pathology that leads to myofiber loss. Sci Rep. 2020;10 (1):17248. doi: 10.1038/s41598-020-74192-9. PubMed PMID:33057110 PubMed Central PMC7560899.
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