Research Interests
The Baker research group (bakergrp) is interested in electrochemical measurement and instrumentation, with special attention to ion transport and electron transfer at small scales. This opens the door to asking and answering questions in biology, materials science, and environmental measurements. We have developed a suite of electrochemical imaging applications that utilize Scanning ion Conductance Microscopy (SICM) for such measurements. SICM employs nanoscale pipettes for local interrogation and can be applied to quantitative analytical and electrochemical measurements. We have significant interests in single-entity electrochemical measurements, including ion transport at biological interfaces and electron transfer at catalytic nanoparticles. Additional areas of enquiry include surface charge at the nanoscale, electrospray from nanoscale emitters, new methods of high-throughput analysis, applications of machine learning for electrochemical data interpretation, and new carbon materials for electrochemistry.
Awards & Honors
- 2024 Spiers Memorial Lecture, Faraday Discussions
- 2023 Charles N. Reilley Award, Society for Electroanalytical Chemistry
- 2022 Fellow, American Association for the Advancement of Science
- 2021 Fellow, American Chemical Society
- 2021 Award in Electrochemistry, Division of Analytical Chemistry, American Chemical Society
- 2021 NSF Special Creativity Award
- 2019 Chair American Chemical Society Division of Analytical Chemistry
- 2017 Trustee’s Teaching Award Indiana University
- 2014 Fellow, Royal Society of Chemistry
- 2012 Young Investigator Award, Society for Electroanalytical Chemistry
- 2009 Cottrell Scholar Award, Research Corporation for Science Advancement
- 2009 CAREER Award, National Science Foundation
Selected Publications
- Branch, S..; Wang, Y.; Azibere, S.; Soule, L.; Davis, A.; McMahon, T.; Martin, R.S.; Baker, L.A.; Geiger, M.; Spence, D.M. Microfluidic Determination of Cell-derived ATP and Single Cell Pressure Mapping Confirms Benefits of Normoglycemic Stored Red Blood Cells, ACS Meas. Sci. Au, 2025, 5, 511–519. https://doi.org/10.1021/acsmeasuresciau.5c00032
- Alden, S.E.; Wahab, O.J.; Zhang, L.; Vernon, K.; Zhu, B.; Bailey, K.; Ye, X.; Baker, L.A. Optically Transparent Carbon-Silicon Nitride Windows for Correlative Structural and Electrochemical Analysis of Nanomaterials, Anal. Chem., 2025, 97, 11798-11805. https://dx.doi.org/10.1021/acs.analchem.5c01403
- Zhang, L.; Edwards, M.; Wahab, O..J.; Samayoa-Oviedo, H.; Freitas, D. ; Yan, X.; Baker, L.A. Scanning Electrochemical Cell Microscopy for Sub-micrometer Mass Spectrometric Studies of Electrochemical Reactions ACS Electrochemistry, 2025, in press. https://dx.doi.org/10.1021/acselectrochem.5c00095
- Wang, Y.; Shashishekar, M.; Spence, D.M.; Baker, L.A. Subcellular Mechanical Imaging of Erythrocytes with Optically Correlated Scanning Ion Conductance Microscopy, ACS Meas. Sci. Au, 2025, 5, 345-352. https://dx.doi.org/10.1021/acsmeasuresciau.5c00019
- Vernon, K.L.; Pungsriasai, T.; Wahab, O.J.; Alden, S.E.; Zhong, Y.; Choi, M.-H; Verma, E.; Bentley, A.K.; Bailey, K.O; Skrabalak, S.E.; Ye, X.; Willets, K.A.; Baker, L.A. Optically Transparent Carbon Electrodes for Single Entity Electrochemistry, ACS Electrochem., 2025, 1, 93-102. https://doi.org/10.1021/acselectrochem.4c00048
- Wang, Y.; Cristobal, C.; Alden, S.E.; Alanis, K.A.; Srinivasan, R.; Baker, L.A. Electrochemical Imaging of Neurotransmitter Release with Fast-scan Voltammetric Ion Conductance Microscopy Sci. Adv., 2024, 10, eado9322. https://doi.org/10.1126/sciadv.ado9322
- Alden, S.E.; Zhang, L.; Lavrik, N.; Wang, Y.; Thorgaard, S.; Baker, L.A. High-throughput single-entity electrochemistry with microelectrode arrays Anal. Chem, 2024, 96, 9177–9184. https://doi.org/10.1021/acs.analchem.4c01092
- Kulesa, K; Hirtzel, E.; Nguyen, V.; Freitas, D.; Edwards, M. Yan, X. Baker, L.A. Interfacing High-Throughput Electrosynthesis and Mass Spectrometric Analysis of Azines Anal. Chem., 2024, 96, 8249-8253. https://doi.org/10.1021/acs.analchem.4c01110