Research Interests
The Baker research group (bakergrp) is interested in electrochemical measurement and instrumentation, with special attention to ion transport and electron transfer at small scales. This opens the door to asking and answering questions in biology, materials science, and environmental measurements. We have developed a suite of electrochemical imaging applications that utilize Scanning ion Conductance Microscopy (SICM) for such measurements. SICM employs nanoscale pipettes for local interrogation and can be applied to quantitative analytical and electrochemical measurements. We have significant interests in single-entity electrochemical measurements, including ion transport at biological interfaces and electron transfer at catalytic nanoparticles. Additional areas of enquiry include surface charge at the nanoscale, electrospray from nanoscale emitters, new methods of high-throughput analysis, applications of machine learning for electrochemical data interpretation, and new carbon materials for electrochemistry.
Selected Publications
Zhu, C.; Jagdale, G.; Gandolfo, A.; Abney, R.; Zhou, L.; Bish, D.; Raff, J.D.; Baker, L.A. Surface Charge Measurements with Scanning Ion Conductance Microscopy Provides Insights into Nitrous Acid Speciation at the Kaolin Mineral-Air Interface, Enviro. Sci. Tech., 2021, 55, 12233-12242. doi.org/10.1021/acs.est.1c03455
Huang, K.; Castiaux, A.; Podicheti, R.; Rusch, D.B.; Martin, R.S.; Baker, L.A. A Hybrid Nanofiber/Paper Cell Culture Platform for Building a 3D Blood-brain Barrier Model, Small Methods, 2021, 2100592. doi.org/10.1002/smtd.202100592
Zhu, C.; Huang, K.; Wang, Y.; Alanis, K.; Shi, W.; Baker, L.A. Imaging with Ion Channels, Anal. Chem., 2021, 93, 5355-5359. doi.org/10.1021/acs.analchem.1c00224
Choi, M.; Siepser, N.P.; Jeong, S.; Wang, Y.; Jagdale, G.; Ye, X.; Baker, L.A. Probing Single-Particle Electrocatalytic Activity at Facet-Controlled Gold Nanocrystals, Nanoletters, 2020, 20, 1233-1239. dx.doi.org/10.1021/acs.nanolett.9b04640
Huang, K.; Zhou, L.; Alanis, K.; Hou, J.; Baker, L.A. Imaging effects of hyperosmolality on individual tricellular junctions, Chem. Sci., 2020, 11, 1307-1315. dx.doi.org/10.1039/C9SC05114G